Communication frameworks that are extremely effective, intelligent, and secure are required due to the rapid shift from 5G to 6G networks. Through a performance analysis of qubit-driven Massive MIMO-OFDM, this paper investigates the integration of quantum communication concepts into conventional wireless systems. It provides a detailed comparison of quantum bit (qubit) representations and traditional binary bit processing. The study evaluates key performance measures across different channel models, such as Rayleigh and Nakagami-m fading, including Bit Error Rate (BER), spectral efficiency, Peak-to-Average Power Ratio (PAPR), and computational complexity. We demonstrate the potential for better robustness, reduced BER, and increased reliability in difficult wireless situations by incorporating qubit-based modulation, quantum channel estimation, and quantum error correction techniques into the OFDM and Massive MIMO framework. MATLAB simulation results show that qubit-based systems outperform classical binary systems, particularly in scenarios with high user density and mobility, making them a viable choice for upcoming 6G applications. Important information about the benefits and trade-offs of switching from classical to quantum-enhanced wireless communication systems is provided by the comparative study